Article

Beneficial Effects of Bempedoic Acid Treatment in Polycystic Kidney Disease Cells and Mice

2022-08-11

Abstract excerpt

<h4>ABSTRACT</h4> ADPKD has few therapeutic options. Tolvaptan slows disease but has side effects limiting its tolerability. Bempedoic acid (BA), an ATP citrate-lyase (ACLY) inhibitor FDA-approved for hypercholesterolemia, catalyzes a key step in fatty acid/sterol synthesis important for cell proliferation. BA is activated by very long-chain acyl-CoA synthetase (FATP2) expressed primarily in kidney and liver. BA...

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Literature Corpus work: d26c0f6b-b454-5f4a-bd31-f8f2ff3f39cd
DOI: 10.1101/2022.08.09.503392

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