Back to search

Article

High efficiency organoid-derived cyst cultures as a drug discovery platform for polycystic kidney disease

2025-02-20

Abstract excerpt

<h4>ABSTRACT</h4> Autosomal dominant polycystic kidney disease (ADPKD) causes the slow, progressive formation of fluid-filled cysts within the kidney that ultimately leads to renal failure. Despite being the most common genetic kidney disease, the range of therapies for ADPKD is limited. Ureteric bud (UB) organoids derived from human pluripotent stem cells (hPSCs) have been used to model ADPKD. Here, we describe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
550a6a18-def4-52ac-8d9e-3940579d532a
DOI
10.1101/2025.02.16.638545
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
High efficiency organoid-derived cyst cultures as a drug discovery platform for polycystic kidney diseaseDOI 10.1101/2025.02.16.638545
Patient-derived kidney organoids recapitulate ADPKD and facilitate the identification of Rho pathway inhibitors as candidate therapeutics.Semantic proximity
Adult human kidney organoids originate from CD24+ cells and represent an advanced model for adult polycystic kidney diseaseSemantic proximity
Kidney organoid models of polycystic kidney disease: challenges and future directions.Semantic proximity
A novel ADPKD model using kidney organoids derived from disease-specific human iPSCs.Semantic proximity
Human iPSC-derived renal collecting duct organoid model cystogenesis in ADPKDSemantic proximity
Studying Kidney Diseases Using Organoid ModelsSemantic proximity
Kidney Organoids and TubuloidsSemantic proximity
An efficient method to generate kidney organoids at the air-liquid interfaceSemantic proximity
Genetics of cystogenesis in base-edited human organoids reveal therapeutic strategies for polycystic kidney diseaseSemantic proximity
Anti-Polyamine Therapy Restrains Kidney Cyst Growth in an Orthologous Mouse Model of Autosomal Dominant Polycystic Kidney DiseaseSemantic proximity
Investigational agents for autosomal dominant polycystic kidney disease: preclinical and early phase study insights.Semantic proximity
Insights Into the Molecular Mechanisms of Polycystic Kidney DiseasesSemantic proximity
Select a neighboring publication to make it the new centre.