Article

Apelin inhibits cyst growth and improves kidney function in mice with polycystic kidney disease

2026-03-30

Abstract excerpt

<h4>Background</h4> Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited disorder marked by numerous renal cysts that impair kidney function, with about half of affected individuals progressing to kidney failure by midlife. Patients exhibit reduced circulating apelin, a ligand of the apelin receptor, known to regulate cardiovascular function including hypertension. We tested whether diminish...

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Literature Corpus work: 922161f6-5d34-5fbc-9706-0e6661410b1e
DOI: 10.64898/2026.03.26.714294

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