Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Autosomic dominant polycystic kidney disease and metformin: Old knowledge and new insights on retarding progression of chronic kidney disease.

Medicinal research reviews - 1 Jan 2022

Casarella Alessandro, Nicotera Ramona, Zicarelli Maria T, Urso Alessandra, Presta Pierangela, Deodato Francesca, Bolignano Davide, De Sarro Giovambattista, Andreucci Michele, Russo Emilio, Coppolino Giuseppe

Abstract excerpt

Autosomal dominant polycystic kidney disease (ADPKD) is the most common congenital kidney disorder, generally caused by mutations in the PKD1 and PKD2 genes, coding for polycystins 1 and 2. Its pathogenesis is accompanied by alterations of the cAMP, mTOR, MAPK/ERK, and JAK/STAT pathways. ADPKD is clinically characterized by the formation of many growing cysts with kidney enlargement and a progressive damage to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biomedical Research and Pathophysiology
Share to Diabetes Mellitus, Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic and Kidney Cyst Diseases

Share to Kidney

Share to Metformin

Share to Mutation

Share to Polycystic Kidney, Autosomal Dominant

Share to Renal Insufficiency, Chronic

Source

Identifiers

PMID: 34328226
DOI: 10.1002/med.21850

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Autosomic dominant polycystic kidney disease and metformin: Old knowledge and new insights on retarding progression of chronic kidney disease.PMID 34328226Read ↗

Autosomal dominant polycystic kidney disease and pioglitazone for its therapy: a comprehensive review with an emphasis on the molecular pathogenesis and pharmacological aspects.Semantic proximity Read ↗

Insights Into the Molecular Mechanisms of Polycystic Kidney DiseasesSemantic proximity Read ↗

[Pathophysiology, epidemiology, clinical presentation, diagnosis and treatment options for autosomal dominant polycystic kidney disease].Semantic proximity Read ↗

[Research advances in the diagnosis and treatment of Polycystic kidney disease].Semantic proximity Read ↗

Autosomal dominant polycystic kidney disease: Disrupted pathways and potential therapeutic interventions.Semantic proximity Read ↗

New treatment paradigms for ADPKD: moving towards precision medicine.Semantic proximity Read ↗

Metformin improves relevant disease parameters in an autosomal dominant polycystic kidney disease mouse model.Semantic proximity Read ↗

Treatment of autosomal dominant polycystic kidney disease (ADPKD): the new horizon for children with ADPKD.Semantic proximity Read ↗

Autosomal dominant polycystic kidney disease: recent advances in clinical managementSemantic proximity Read ↗

The cellular pathways and potential therapeutics of Polycystic Kidney Disease.Semantic proximity Read ↗

Molecular pathways and therapies in autosomal-dominant polycystic kidney disease.Semantic proximity Read ↗

Polycystic kidney diseases: from molecular discoveries to targeted therapeutic strategies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.