Article

Circadian clock disruption and growth of kidney cysts in autosomal dominant polycystic kidney disease

2024-08-05

Abstract excerpt

<h4>Background</h4> Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in the PKD1 and PKD2 genes, and often progresses to kidney failure. ADPKD progression is not uniform among patients, suggesting that factors secondary to the PKD1/2 gene mutation could regulate the rate of disease progression. Here we tested the effect of circadian clock disruption on ADPKD progression. Circadian rh...

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Literature Corpus work: acdf9448-6846-559e-823d-e0d7c3b65171
DOI: 10.1101/2024.08.05.606676

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