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Article

Metformin improves relevant disease parameters in an autosomal dominant polycystic kidney disease mouse model.

American journal of physiology. Renal physiology - 1 Jan 2022

Pastor-Soler Núria M, Li Hui, Pham Jessica, Rivera Daniel, Ho Pei-Yin, Mancino Valeria, Saitta Biagio, Hallows Kenneth R

Abstract excerpt

Autosomal dominant polycystic kidney disease (ADPKD), caused by mutations in the polycystin 1 (PKD1) or polycystin 2 genes, presents with progressive development of kidney cysts and eventual end-stage kidney disease with limited treatment options. Previous work has shown that metformin reduces cyst growth in rapid ADPKD mouse models via inhibition of cystic fibrosis transmembrane conductance regulator-mediated...

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PMID: 34806449
DOI: 10.1152/ajprenal.00298.2021

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