The cellular pathways and potential therapeutics of Polycystic Kidney Disease.

doi:10.1042/BST20200757

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Article

The cellular pathways and potential therapeutics of Polycystic Kidney Disease.

Biochemical Society transactions - 30 Jun 2021

Richards Taylor, Modarage Kavindiya, Malik Soniya A, Goggolidou Paraskevi

Abstract excerpt

Polycystic Kidney Disease (PKD) refers to a group of disorders, driven by the formation of cysts in renal tubular cells and is currently one of the leading causes of end-stage renal disease. The range of symptoms observed in PKD is due to mutations in cilia-localising genes, resulting in changes in cellular signalling. As such, compounds that are currently in preclinical and clinical trials target some of these...

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PMID: 34156429
DOI: 10.1042/BST20200757

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