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Article

microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism

16 Feb 2017

Abstract excerpt

Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent genetic cause of renal failure. Here we identify miR-17 as a target for the treatment of ADPKD. We report that miR-17 is induced in kidney cysts of mouse and human ADPKD. Genetic deletion of the miR-17∼92 cluster inhibits cyst proliferation and PKD progression in four orthologous, including two long-lived, mouse models of ADPKD. Anti-miR-17...

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PMID: 28205547
DOI: 10.1038/ncomms14395

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