Article

Automated <i>in situ</i> profiling of chromatin modifications resolves cell types and gene regulatory programs

2018-09-16

Abstract excerpt

Our understanding of eukaryotic gene regulation is limited by the complexity of protein-DNA interactions that comprise the chromatin landscape and by inefficient methods for characterizing these interactions. We recently introduced CUT&RUN, an antibody-targeted nuclease-cleavage method that profiles DNA-binding proteins, histones and chromatin modifying proteins in situ with exceptional sensitivity and resolution...

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Literature Corpus work: d248fb3d-582e-56eb-9a82-e92fd867d777
DOI: 10.1101/418681

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