Article

Mapping chromatin accessibility and active regulatory elements reveals new pathological mechanisms in human gliomas

2019-12-06

Abstract excerpt

<h4>Summary</h4> Chromatin structure and accessibility, and combinatorial binding of transcription factors to regulatory elements in genomic DNA control transcription. Genetic variations in genes encoding histones, epigenetics-related enzymes or modifiers affect chromatin structure/dynamics and result in alterations in gene expression contributing to cancer development or progression. Gliomas are brain tumors fre...

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Literature Corpus work: eb1b317b-063d-5d25-a218-28e282c2d737
DOI: 10.1101/867861

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