Article

Chromatin run-on reveals the transcriptional etiology of glioblastoma multiforme

2017-09-07

Abstract excerpt

The human genome encodes a variety of poorly understood RNA species that remain challenging to identify using existing genomic tools. We developed chromatin run-on and sequencing (ChRO-seq) to map the location of RNA polymerase using virtually any input sample, including samples with degraded RNA that are intractable to conventional RNA-seq. We used ChRO-seq to develop the first maps of nascent transcription in pr...

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Literature Corpus work: 5864d2a3-8128-5e61-ae87-576b621deebc
DOI: 10.1101/185991

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