Article
Allele-level visualization of transcription and chromatin by high-throughput imaging.
Histochemistry and cell biology - 1 Jul 2024
Almansour Faisal, Keikhosravi Adib, Pegoraro Gianluca, Misteli Tom
Abstract excerpt
The spatial arrangement of the genome within the nucleus is a pivotal aspect of cellular organization and function with implications for gene expression and regulation. While all genome organization features, such as loops, domains, and radial positioning, are nonrandom, they are characterized by a high degree of single-cell variability. Imaging approaches are ideally suited to visualize, measure, and study...
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