Article
Structural basis for feedforward control in the PINK1/parkin pathway
2021-08-17
Abstract excerpt
<h4>ABSTRACT</h4> PINK1 and parkin constitute a mitochondrial quality control system mutated in Parkinson’s disease. PINK1, a kinase, phosphorylates ubiquitin to recruit parkin, an E3 ubiquitin ligase, to mitochondria. PINK1 controls both parkin localization and activity through phosphorylation of both ubiquitin and the ubiquitin-like (Ubl) domain of parkin. Here, we observe that phospho-ubiquitin can bind to two...
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Identifiers and source
- Literature Corpus work
- d22d32ee-a688-53f0-af11-5424e19a7499
- DOI
- 10.1101/2021.08.16.456440