Article

Additional feedforward mechanism of Parkin activation via binding of phospho-UBL and RING0 in trans

2024-06-25

Abstract excerpt

<title>Abstract</title> <p>Loss of function Parkin mutations lead to early-onset of Parkinson’s disease. Parkin is an auto-inhibited ubiquitin E3 ligase activated by dual phosphorylation of its ubiquitin-like (Ubl) domain and ubiquitin by the PINK1 kinase. Herein, we demonstrate a competitive binding of the phospho-Ubl and RING2 domains towards the RING0 domain, which regulates Parkin activity. We show that phosp...

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Literature Corpus work: cf8d21c3-e469-5753-baa5-c05997d59474
DOI: 10.21203/rs.3.rs-2859540/v5

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