Article

Mechanism of Gating and Isoform-Specific Inhibition in Renal CLC Chloride Channels

2026-02-18

Abstract excerpt

Hyponatremia is a prevalent disorder marked by excess water retention and substantial morbidity, motivating interest in the CLC-Ka chloride channel as a therapeutic target. Selectively inhibiting CLC-Ka without affecting the closely related CLC-Kb is essential for preventing serious side effects. However, developing isoform-selective inhibitors has been challenging because most small molecules do not distinguish b...

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Literature Corpus work: d21d326e-75de-5d1d-842a-799bac95fbbc
DOI: 10.64898/2026.02.17.706469

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