Article

An allosteric pocket in KV1.3 defines a distinct chemical space for immunomodulator design

2026-07-17

Abstract excerpt

<title>Abstract</title> <p>KV1.3 is a validated autoimmune drug target, yet all disclosed inhibitors converge on a narrow set of conserved binding sites, suffering from poor selectivity or clinical failure. Whether KV1.3 harbors a distinctive, druggable pocket amenable to selective targeting has remained elusive. Here we identify a previously uncharacterized extracellular allosteric pocket in KV1.3 through functi...

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Literature Corpus work: fe354f91-cbab-56df-ae11-5e0f303cfcd6
DOI: 10.21203/rs.3.rs-10321939/v1

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