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Article

A selective class of inhibitors for the CLC-Ka chloride ion channel.

Proceedings of the National Academy of Sciences of the United States of America - 22 May 2018

Koster Anna K, Wood Chase A P, Thomas-Tran Rhiannon, Chavan Tanmay S, Almqvist Jonas, Choi Kee-Hyun, Du Bois J, Maduke Merritt

Abstract excerpt

CLC proteins are a ubiquitously expressed family of chloride-selective ion channels and transporters. A dearth of pharmacological tools for modulating CLC gating and ion conduction limits investigations aimed at understanding CLC structure/function and physiology. Herein, we describe the design, synthesis, and evaluation of a collection of N-arylated benzimidazole derivatives (BIMs), one of which (BIM1) shows...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29669921
DOI: 10.1073/pnas.1720584115
PMCID: PMC6003504

Genes

CLC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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