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Article

In silico model of the human ClC-Kb chloride channel: pore mapping, biostructural pathology and drug screening.

Scientific reports - 3 Aug 2017

Louet Maxime, Bitam Sara, Bakouh Naziha, Bignon Yohan, Planelles Gabrielle, Lagorce David, Miteva Maria A, Eladari Dominique, Teulon Jacques, Villoutreix Bruno O

Abstract excerpt

The human ClC-Kb channel plays a key role in exporting chloride ions from the cytosol and is known to be involved in Bartter syndrome type 3 when its permeation capacity is decreased. The ClC-Kb channel has been recently proposed as a potential therapeutic target to treat hypertension. In order to gain new insights into the sequence-structure-function relationships of this channel, to investigate possible impacts...

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Identifiers

PMID: 28775266
DOI: 10.1038/s41598-017-07794-5
PMCID: PMC5543074

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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