Article

YTHDC1 cooperates with the THO complex to prevent RNA damage-induced DNA breaks

2024-03-14

Abstract excerpt

<h4>Summary</h4> Certain environmental toxins are nucleic acid damaging agents, as are many chemotherapeutics used for cancer therapy. These agents induce various adducts in DNA as well as RNA. Indeed, most of the nucleic acid adducts (>90%) formed due to these chemicals, such as alkylating agents, occur in RNA 1 . However, compared to the well-studied mechanisms for DNA alkylation repair, the biological consequ...

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Literature Corpus work: d216c6d5-c139-58a7-b1c0-a2a8066486f5
DOI: 10.1101/2024.03.14.585107

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