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Article

Heterogeneous nuclear ribonucleoprotein E1 binds polycytosine DNA and monitors genome integrity.

Life science alliance - 1 Sept 2021

Mohanty Bidyut K, Karam Joseph Aq, Howley Breege V, Dalton Annamarie C, Grelet Simon, Dincman Toros, Streitfeld William S, Yoon Je-Hyun, Balakrishnan Lata, Chazin Walter J, Long David T, Howe Philip H

Abstract excerpt

Heterogeneous nuclear ribonucleoprotein E1 (hnRNP E1) is a tumor suppressor protein that binds site- and structure-specifically to RNA sequences to regulate mRNA stability, facilitate alternative splicing, and suppress protein translation on several metastasis-associated mRNAs. Here, we show that hnRNP E1 binds polycytosine-rich DNA tracts present throughout the genome, including those at promoters of several...

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Identifiers

PMID: 34272328
DOI: 10.26508/lsa.202000995
PMCID: PMC8321654

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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