Article

YTHDC1 drives senescence evasion in ovarian cancer through m6A-mediated TERT Stabilization

2025-11-19

Abstract excerpt

<title>Abstract</title> <p>N6-methyladenosine (m6A) represents the most abundant internal RNA modification, and a key regulator of gene expression, yet its role in determining cell fate decisions such as senescence remains largely unexplored. Here, we identify the nuclear m6A reader YTHDC1 as a critical regulator of telomere homeostasis and senescence evasion in ovarian cancer. YTHDC1 expression was markedly elev...

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Literature Corpus work: 7b38c08c-c08b-5b71-8307-c2f1eeb2caed
DOI: 10.21203/rs.3.rs-7970749/v1

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