Differences in Clinical Features and Comorbid Burden between HLA-C∗06:02 Carrier Groups in >9,000 People with Psoriasis.

doi:10.1016/j.jid.2021.08.446

Article

Differences in Clinical Features and Comorbid Burden between HLA-C∗06:02 Carrier Groups in >9,000 People with Psoriasis.

The Journal of investigative dermatology - 1 Jun 2022

Douroudis Konstantinos, Ramessur Ravi, Barbosa Ines A, Baudry David, Duckworth Michael, Angit Caroline, Capon Francesca, Chung Raymond, Curtis Charles J, Di Meglio Paola, Goulding Jonathan M R, Griffiths Christopher E M, Lee Sang Hyuck, Mahil Satveer K, Parslew Richard, Reynolds Nick J, Shipman Alexa R, Warren Richard B, Yiu Zenas Z N, Simpson Michael A, Barker Jonathan N, Dand Nick, Smith Catherine H

Abstract excerpt

The identification of robust endotypes-disease subgroups of clinical relevance-is fundamental to stratified medicine. We hypothesized that HLA-C∗06:02 status, the major genetic determinant of psoriasis, defines a psoriasis endotype of clinical relevance. Using two United Kingdom-based cross-sectional datasets-an observational severe-psoriasis study (Biomarkers of Systemic Treatment Outcomes in Psoriasis; n =...

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Differences in Clinical Features and Comorbid Burden between HLA-C∗06:02 Carrier Groups in >9,000 People with Psoriasis.

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