Article
A cross-population atlas of genetic associations for 220 human phenotypes.
Nature genetics - 1 Oct 2021
Sakaue Saori, Kanai Masahiro, Tanigawa Yosuke, Karjalainen Juha, Kurki Mitja, Koshiba Seizo, Narita Akira, Konuma Takahiro, Yamamoto Kenichi, Akiyama Masato, Ishigaki Kazuyoshi, Suzuki Akari, Suzuki Ken, Obara Wataru, Yamaji Ken, Takahashi Kazuhisa, Asai Satoshi, Takahashi Yasuo, Suzuki Takao, Shinozaki Nobuaki, Yamaguchi Hiroki, Minami Shiro, Murayama Shigeo, Yoshimori Kozo, Nagayama Satoshi, Obata Daisuke, Higashiyama Masahiko, Masumoto Akihide, Koretsune Yukihiro, Ito Kaoru, Terao Chikashi, Yamauchi Toshimasa, Komuro Issei, Kadowaki Takashi, Tamiya Gen, Yamamoto Masayuki, Nakamura Yusuke, Kubo Michiaki, Murakami Yoshinori, Yamamoto Kazuhiko, Kamatani Yoichiro, Palotie Aarno, Rivas Manuel A, Daly Mark J, Matsuda Koichi, Okada Yukinori
Abstract excerpt
Current genome-wide association studies do not yet capture sufficient diversity in populations and scope of phenotypes. To expand an atlas of genetic associations in non-European populations, we conducted 220 deep-phenotype genome-wide association studies (diseases, biomarkers and medication usage) in BioBank Japan (n = 179,000), by incorporating past medical history and text-mining of electronic medical records....
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