Article

Deep Learning Analysis on Images of iPSC-derived Motor Neurons Carrying fALS-genetics Reveals Disease-Relevant Phenotypes

2024-01-05

Abstract excerpt

<h4>Summary</h4> Amyotrophic lateral sclerosis (ALS) is a devastating condition with very limited treatment options. It is a heterogeneous disease with complex genetics and unclear etiology, making the discovery of disease-modifying interventions very challenging. To discover novel mechanisms underlying ALS, we leverage a unique platform that combines isogenic, induced pluripotent stem cell (iPSC)-derived models...

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Literature Corpus work: d1f874c8-ccba-52dc-bcf8-92d1decd7e29
DOI: 10.1101/2024.01.04.574270

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