Article

Integrating deep learning and unbiased automated high-content screening to identify complex disease signatures in human fibroblasts

2020-11-16

Abstract excerpt

Drug discovery for diseases such as Parkinson’s disease are impeded by the lack of screenable cellular phenotypes. We present an unbiased phenotypic profiling platform that combines automated cell culture, high-content imaging, Cell Painting, and deep learning. We applied this platform to primary fibroblasts from 91 Parkinson’s disease patients and matched healthy controls, creating the largest publicly available...

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Literature Corpus work: ab4aff1c-6203-51ae-8d53-ef8ab40137aa
DOI: 10.1101/2020.11.13.380576

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