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Image-based deep learning reveals the responses of human motor neurons to stress and VCP-related ALS.

Neuropathology and applied neurobiology - 1 Feb 2022

Verzat Colombine, Harley Jasmine, Patani Rickie, Luisier Raphaëlle

Abstract excerpt

AIMS: Although morphological attributes of cells and their substructures are recognised readouts of physiological or pathophysiological states, these have been relatively understudied in amyotrophic lateral sclerosis (ALS) research. METHODS: In this study, we integrate multichannel fluorescence high-content microscopy data with deep learning imaging methods to reveal-directly from unsegmented images-novel...

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Identifiers

PMID: 34595747
DOI: 10.1111/nan.12770
PMCID: PMC9298273

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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