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Article

High-content phenotyping of Parkinson's disease patient stem cell-derived midbrain dopaminergic neurons using machine learning classification.

Stem cell reports - 11 Oct 2022

Vuidel Aurore, Cousin Loïc, Weykopf Beatrice, Haupt Simone, Hanifehlou Zahra, Wiest-Daesslé Nicolas, Segschneider Michaela, Lee Joohyun, Kwon Yong-Jun, Peitz Michael, Ogier Arnaud, Brino Laurent, Brüstle Oliver, Sommer Peter, Wilbertz Johannes H

Abstract excerpt

Combining multiple Parkinson's disease (PD) relevant cellular phenotypes might increase the accuracy of midbrain dopaminergic neuron (mDAN) in vitro models. We differentiated patient-derived induced pluripotent stem cells (iPSCs) with a LRRK2 G2019S mutation, isogenic control, and genetically unrelated iPSCs into mDANs. Using automated fluorescence microscopy in 384-well-plate format, we identified elevated...

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Identifiers

PMID: 36179692
DOI: 10.1016/j.stemcr.2022.09.001
PMCID: PMC9561636

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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