Article

ALS molecular subtypes are a combination of cellular, genetic, and pathological features learned by deep multiomics classifiers

2024-07-20

Abstract excerpt

Amyotrophic Lateral Sclerosis (ALS) is a complex syndrome with multiple genetic causes and wide variation in disease presentation. Despite this general heterogeneity, several common factors have been identified. For example, nearly all patients show pathological accumulations of phosphorylated TDP-43 protein in affected regions of the motor cortex and spinal cord. Moreover, large patient cohort studies have reveal...

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Literature Corpus work: 5e2d7416-c966-5daf-a933-7abbe285fd74
DOI: 10.1101/2024.07.19.603731

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