Article

Using image classifiers to predict CMT2A disease-relevant mitochondrial motility phenotypes in iPSC motor neurons

2026-03-17

Abstract excerpt

<h4>ABSTRACT</h4> Charcot-Marie-Tooth disease type 2A (CMT2A) is a genetic disease characterized by autosomal dominant MFN2 mutations and dysregulated mitochondrial trafficking. While there is currently no FDA-approved CMT2A therapy, the recent development of iPSC motor neuron model systems, high-throughput imaging platforms, and CRISPR-based gene editing technologies holds promise for screening new therapies at...

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Literature Corpus work: 454d1a81-de44-5be8-885d-9c61de21ff53
DOI: 10.64898/2026.03.16.712192

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