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Identifying FUS amyotrophic lateral sclerosis disease signatures in patient dermal fibroblasts.

Developmental cell - 19 Aug 2024

Kumbier Karl, Roth Maike, Li Zizheng, Lazzari-Dean Julia, Waters Christopher, Hammerlindl Sabrina, Rinaldi Capria, Huang Ping, Korben Vlad A, Phatnani Hemali, Shneider Neil, Jacobson Matthew P, Wu Lani F, Altschuler Steven J

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a rapidly progressing, highly heterogeneous neurodegenerative disease, underscoring the importance of obtaining information to personalize clinical decisions quickly after diagnosis. Here, we investigated whether ALS-relevant signatures can be detected directly from biopsied patient fibroblasts. We profiled familial ALS (fALS) fibroblasts, representing a range of mutations...

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Identifiers

PMID: 38878774
DOI: 10.1016/j.devcel.2024.05.011

Genes

FUS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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