Article

Deciphering the tissue-specific functional effect of Alzheimer risk SNPs with deep genome annotation

2023-10-23

Abstract excerpt

Alzheimer’s disease (AD) is a highly heritable brain dementia, along with substantial failure of cognitive function. Large-scale genome-wide association studies (GWAS) have led to a significant set of SNPs associated with AD and related traits. GWAS hits usually emerge as clusters where a lead SNP with the highest significance is surrounded by other less significant neighboring SNPs. Although functionality is not...

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Literature Corpus work: d1df6a4b-25a0-5c84-9767-06ebf13f35da
DOI: 10.1101/2023.10.23.23297399

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