Article
Unraveling the biological mechanisms in Alzheimer's disease--lessons from genomics.
Progress in neuro-psychopharmacology & biological psychiatry - 30 Mar 2011
Borovecki Fran, Klepac Natasa, Muck-Seler Dorotea, Hajnsek Sanja, Mubrin Zdenko, Pivac Nela
Abstract excerpt
Alzheimer's disease (AD) is the most common form of dementia and the most common neurodegenerative disease, with a complex genetic background. Genome-wide association studies (GWAS) have yielded important new insights into genetic mechanisms of AD pathology. Current results unequivocally confirm apolipoprotein E (APOE) as a major genetic risk factor for development of late onset AD. Additional associations of...
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