Article

Coordinated protein modules define DNA damage responses to carboplatin at single cell resolution in human ovarian carcinoma models

2024-11-22

Abstract excerpt

Tubo-ovarian high-grade serous carcinoma (HGSC) is the most lethal gynecological malignancy and frequently responds to platinum-based chemotherapy because of common genetic and somatic impairment of DNA damage repair (DDR) pathways. The mechanisms of clinical platinum resistance are diverse and poorly molecularly defined. Consequently, there are no biomarkers or medicines that improve patient outcomes. Herein we u...

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Literature Corpus work: d1b91e85-c246-5e4d-b40c-f3bb70ecfe25
DOI: 10.1101/2024.11.21.624591

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