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Systems-Level Mapping of the Tumor Microenvironment Reveals Immune-Mediated Mechanisms and Potential Targets in Platinum-Resistant Ovarian Cancer

2026-07-22

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<title>Abstract</title> <p>Background: Ovarian cancer remains the most lethal gynecologic cancer, with limited improvements in patient survival despite targeted therapies and a high recurrence rate (~80%). Current standard-of-care for frontline treatment involves platinum-based chemotherapy, but the emergence of resistant clones limits long-term efficacy. Existing models often overlook critical interactions betwe...

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Literature Corpus work
97089499-2910-5567-a1aa-959cee42ce63
DOI
10.21203/rs.3.rs-10385637/v1
Open publication

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