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Article

Proteomic landscape of epithelial ovarian cancer.

Nature communications - 31 Jul 2024

Qian Liujia, Zhu Jianqing, Xue Zhangzhi, Zhou Yan, Xiang Nan, Xu Hong, Sun Rui, Gong Wangang, Cai Xue, Sun Lu, Ge Weigang, Liu Yufeng, Su Ying, Lin Wangmin, Zhan Yuecheng, Wang Junjian, Song Shuang, Yi Xiao, Ni Maowei, Zhu Yi, Hua Yuejin, Zheng Zhiguo, Guo Tiannan

Abstract excerpt

Epithelial ovarian cancer (EOC) is a deadly disease with limited diagnostic biomarkers and therapeutic targets. Here we conduct a comprehensive proteomic profiling of ovarian tissue and plasma samples from 813 patients with different histotypes and therapeutic regimens, covering the expression of 10,715 proteins. We identify eight proteins associated with tumor malignancy in the tissue specimens, which are...

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Identifiers

PMID: 39085232
DOI: 10.1038/s41467-024-50786-z
PMCID: PMC11291745

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