Cell-intrinsic platinum response and associated genetic and gene expression signatures in ovarian cancer

Abstract excerpt

Abstract Ovarian cancers are still largely treated with platinum-based chemotherapy as the standard of care, yet few biomarkers of clinical response have had an impact on clinical decision making. Previous work has relied on poor models of the most common subtypes of epithelial ovarian cancers and necessitates a careful examination of the most suitable in vitro models. We performed extensive drug dose response...

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