Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deep visual proteomics reveals DNA replication stress as a hallmark of signet ring cell carcinoma

5 Feb 2025

Abstract excerpt

Signet Ring Cell Carcinoma (SRCC) is a rare and highly malignant form of adenocarcinoma with increasing incidence and poor prognosis due to late diagnosis and limited treatment options. We employed Deep Visual Proteomics (DVP), which combines AI-directed cell segmentation and classification with laser microdissection and ultra-high sensitivity mass spectrometry, for cell-type-specific proteomic analysis of SRCC...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer and Skin Lesions
Share to Cancer-related Molecular Pathways
Share to Nonmelanoma Skin Cancer Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39910169
DOI: 10.1038/s41698-025-00819-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deep visual proteomics reveals DNA replication stress as a hallmark of signet ring cell carcinomaPMID 39910169Read ↗

Targeting DNA Damage Response and Replication Stress in Pancreatic CancerSemantic proximity Read ↗

Single-cell proteomics: potential implications for cancer diagnostics.Semantic proximity Read ↗

Deep visual multi-omics profiling reveals mechanisms that underlie cancer cell differentiation and aggressiveness in clear cell renal cell carcinomaSemantic proximity Read ↗

Histopathology and proteomics are synergistic for High-Grade Serous Ovarian Cancer platinum response predictionSemantic proximity Read ↗

Histopathology and proteomics are synergistic for High-Grade Serous Ovarian Cancer platinum response predictionSemantic proximity Read ↗

Deep spatial-omics to aid personalization of precision medicine in metastatic recurrent Head & Neck CancersSemantic proximity Read ↗

Proteomic analysis reveals key differences between squamous cell carcinomas and adenocarcinomas across multiple tissuesSemantic proximity Read ↗

Democratised single cell proteomics uncovers tumor associated macrophage signature in CYLD cutaneous syndrome skin tumorsSemantic proximity Read ↗

Pan-cancer proteogenomic landscape of whole-genome doubling reveals putative therapeutic targets in various cancer typesSemantic proximity Read ↗

Coordinated protein modules define DNA damage responses to carboplatin at single cell resolution in human ovarian carcinoma modelsSemantic proximity Read ↗

AI-driven Deep Visual Proteomics defines cell identity and heterogeneitySemantic proximity Read ↗

Single-cell sequencing reveals novel proliferative cell type: a key player in renal cell carcinoma prognosis and therapeutic responseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.