Article

Heme synthesis inhibition blocks angiogenesis via mitochondrial dysfunction

2019-11-09

Abstract excerpt

The relationship between heme metabolism and angiogenesis is poorly understood. The final synthesis of heme occurs in mitochondria, where ferrochelatase (FECH) inserts Fe 2+ into protoporphyrin IX to produce proto-heme IX. We previously showed that FECH inhibition is antiangiogenic in human retinal microvascular endothelial cells (HRECs) and in animal models of ocular neovascularization. In the present study, we...

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Literature Corpus work: 9f657672-3dda-5075-9092-1b4ecddd4377
DOI: 10.1101/836304

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