Article

Interplay between ferroptosis and guttae in an early-onset murine model of Fuchs’ endothelial corneal dystrophy (FECD)

2026-07-10

Abstract excerpt

Col8a2 Q455K/Q455K (Q455K) mice exhibit features of early-onset Fuchs’ endothelial corneal dystrophy (FECD), including decreased endothelial cell density (ECD) and guttae formation. Within the context of these clinical features, this study longitudinally evaluates ferroptosis in Q455K and wild-type (WT) mice using in vivo imaging, PCR and immunohistochemistry. Fifty-six Q455K and 56 WT mice were evaluated from 3...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e29cbd51-8f31-53b2-b390-c06456c5c77e
DOI: 10.64898/2026.07.09.737597

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Interplay between ferroptosis and guttae in an early-onset murine model of Fuchs’ endothelial corneal dystrophy (FECD)DOI 10.64898/2026.07.09.737597Read

L450W and Q455K Col8a2 knock-in mouse models of Fuchs endothelial corneal dystrophy show distinct phenotypes and evidence for altered autophagy.Semantic proximity Read

Early Transcriptomic and Pathologic Changes of Col8a2 Mutant Fuchs Endothelial Corneal Dystrophy.Semantic proximity Read

Characterization of a novel mouse model for Fuchs Endothelial Corneal DystrophySemantic proximity Read

Preclinical Models for Studying Fuchs Endothelial Corneal DystrophySemantic proximity Read

An alpha 2 collagen VIII transgenic knock-in mouse model of Fuchs endothelial corneal dystrophy shows early endothelial cell unfolded protein response and apoptosis.Semantic proximity Read

Generation of a Mouse Model of Fuchs Endothelial Corneal Dystrophy by Knock-in of CTG Trinucleotide Repeat Expansion in the TCF4 Gene.Semantic proximity Read

<i>TCF4</i> trinucleotide repeat expansions and UV irradiation increase susceptibility to ferroptosis in Fuchs endothelial corneal dystrophySemantic proximity Read

Proteasomal Dysfunction results in ER stress, Endo MT, oxidative stress, and apoptotic cell death resulting in Fuchs Corneal Endothelial Dystrophy like features in miceSemantic proximity Read

TCF4 trinucleotide repeat expansions and UV irradiation increase susceptibility to ferroptosis in Fuchs endothelial corneal dystrophySemantic proximity Read

TAZ ( <i>Wwtr1</i> ) deficiency leads to ER stress and mitochondrial dysfunction in a mouse model of Fuchs’ endothelial corneal dystrophySemantic proximity Read

Fuchs endothelial corneal dystrophy: current perspectives on diagnostic pathology and genetics—Bowman Club LectureSemantic proximity Read

Endothelial cell whole genome expression analysis in a mouse model of early-onset Fuchs' endothelial corneal dystrophy.Semantic proximity Read