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Article

The role of Fas-FasL in the development and treatment of ischemic retinopathy.

Investigative ophthalmology & visual science - 1 Mar 2003

Barreiro Ramon, Schadlu Ramin, Herndon John, Kaplan Henry J, Ferguson Thomas A

Abstract excerpt

PURPOSE: Define a role for Fas-FasL in oxygen-induced retinopathy and explore the mechanism of pigment-epithelium-derived growth factor (PEDF) inhibition in this model. METHODS: Seven-day-old mice C57BL/6J (B6), FasL-defective (B6-gld), or Fas-defective (B6-lpr) mice were exposed to 75% oxygen for 5 days (postnatal day [P]7-P12) and returned to room air. On day P17, vascular architecture was assessed...

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Source

Identifiers

PMID: 12601060
DOI: 10.1167/iovs.02-0478

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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