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Article

Deguelin inhibits retinal neovascularization by down‐regulation of HIF‐1α in oxygen‐induced retinopathy

19 Jan 2008

Abstract excerpt

Retinal neovascularization is the most common cause of blindness; Retinopathy of pre-maturity (ROP) for children and diabetic retinopathy for young age group. ROP still remains as the most serious cause of vision loss in children. We provided that deguelin significantly reduces retinal neovascularization in a mouse model of ROP. Deguelin never affected the transcriptional activity of hypoxia inducible factor...

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Share to Mitochondrial Function and Pathology
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Identifiers

PMID: 18208562
DOI: 10.1111/j.1582-4934.2008.00243.x

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