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Vorapaxar and aripiprazole suppress hepatitis B virus replication through distinct host signaling pathways

2026-08-09

Abstract excerpt

<h4>Background & Aims</h4> Current nucleos(t)ide analogs efficiently suppress hepatitis B virus (HBV) replication but have limited effects on viral transcription from covalently closed circular DNA (cccDNA) and integrated HBV DNA. We aimed to identify clinically applicable compounds that directly inhibit HBV transcription by screening FDA-approved drugs. <h4>Approach & Results</h4> Screening of 1,470 FDA-approve...

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Literature Corpus work
d1b17845-6b5d-59ae-a583-eae02df57036
DOI
10.64898/2026.08.05.743121
Open publication

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Vorapaxar and aripiprazole suppress hepatitis B virus replication through distinct host signaling pathwaysDOI 10.64898/2026.08.05.743121
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