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Article

Spiperone targets HBV cccDNA via ER stress–induced innate immune activation and epigenetic silencing

2026-04-01

Abstract excerpt

Chronic hepatitis B persists due to the stability of nuclear covalently closed circular DNA (cccDNA), which maintains viral transcription despite prolonged antiviral therapy, highlighting the need for strategies that suppress cccDNA via host-targeted mechanisms. Here, we identify Spiperone, a clinically approved compound, as a repurposed anti-HBV candidate with strong translational potential. Spiperone robustly re...

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Identifiers and source

Literature Corpus work
639844ef-f7b0-53d0-8257-ad0559797f1d
DOI
10.64898/2026.03.31.715751
Open publication

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Spiperone targets HBV cccDNA via ER stress–induced innate immune activation and epigenetic silencingDOI 10.64898/2026.03.31.715751
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