Article

Targeting POLR1A induces apoptosis and inhibits hepatocellular carcinoma proliferation through upregulation of IFI27 transcription

2026-02-16

Abstract excerpt

<title>Abstract</title> <p> <bold>Objective</bold> Evasion of apoptosis and uncontrolled proliferation are hallmarks of cancer. RNA Polymerase I Subunit A (POLR1A), the catalytic core of RNA Polymerase I, is highly expressed in various tumors and exerts a cancer-promoting effect; however, its expression in hepatocellular carcinoma remain unclear.This study aims to delineate the oncogenic role, regulatory mechan...

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Literature Corpus work: d6145d10-1586-5b9e-a498-eab4ab59acd1
DOI: 10.21203/rs.3.rs-8584114/v1

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