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A human and rhesus macaque interferon-stimulated gene screen reveals <i>ARHGEF3/XPLN</i> as an antiviral gene against hepatitis C virus and other flaviviruses

2022-05-12

Abstract excerpt

Natural hepatitis C virus (HCV) infection is restricted to humans whereas in other primates such as rhesus macaques, the virus is non-permissive. To identify human and rhesus macaque genes that differ or share the ability to inhibit HCV replication, we conducted a medium-throughput screen of lentivirus-expressed host genes that disrupt replication of HCV subgenomic replicon RNA expressing secreted Gaussia lucifer...

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Literature Corpus work
bb8402f0-ff10-5b5f-b4d4-cf21ce8a5cc2
DOI
10.1101/2022.05.12.491650
Open publication

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A human and rhesus macaque interferon-stimulated gene screen reveals <i>ARHGEF3/XPLN</i> as an antiviral gene against hepatitis C virus and other flavivirusesDOI 10.1101/2022.05.12.491650
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