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THE DUAL-SPECIFICITY KINASE DYRK1A INTERACTS WITH THE HEPATITIS B VIRUS GENOME AND REGULATES THE PRODUCTION OF VIRAL RNA

2024-06-03

Abstract excerpt

<h4>ABSTRACT</h4> The genome of Hepatitis B virus (HBV) persists in infected hepatocytes as a nuclear episome (cccDNA) that is responsible for the transcription of viral genes and viral rebound, following antiviral treatment arrest in chronically infected patients. Beside pegylated interferon-alpha, there is currently no clinically approved therapeutic protocol able to target cccDNA [1]. The development of altern...

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Literature Corpus work: 37a0b665-4136-58cb-be2d-21c66c420659
DOI: 10.1101/2024.05.30.596758

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