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Identification of novel antiviral host factors by functional gene expression analysis using in vitro HBV infection assay systems

6 Mar 2025

Abstract excerpt

To cure hepatitis B virus (HBV) infection, it is essential to elucidate the function of hepatocyte host factors in regulating the viral life cycle. Signaling and transcription activator of transcription (STAT)1 play important roles in immune responses, but STAT1-independent pathways have also been shown to have important biological reactivity. Using an in vitro HBV infection assay system, the current study aimed...

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PMID: 40048440
DOI: 10.1371/journal.pone.0314581

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