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A hnRNPA2B1 agonist effectively inhibits HBV and SARS-CoV-2 omicronin vivo

15 Jul 2022

Abstract excerpt

The twenty-first century has already recorded more than ten major epidemics or pandemics of viral disease, including the devastating COVID-19. Novel effective antivirals with broad-spectrum coverage are urgently needed. Herein, we reported a novel broad-spectrum antiviral compound PAC5. Oral administration of PAC5 eliminated HBV cccDNA and reduced the large antigen load in distinct mouse models of HBV infection....

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PMID: 36726760
DOI: 10.1093/procel/pwac027

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