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The histone variant H2A.Z and its chaperone SRCAP are required for RNA polymerase II to access HBV chromatin

2025-11-11

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Chronic hepatitis B virus (HBV) infection remains a major global health burden due to the persistence of covalently closed circular DNA (cccDNA), a stable episomal viral reservoir resistant to current antiviral therapies. The transcriptional activity of cccDNA depends on its chromatin organization, yet the contribution of histone variants to this regulation remains poorly un...

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Literature Corpus work
3ed26610-d268-5a4c-80c0-92b527f2e778
DOI
10.1101/2025.11.10.687638
Open publication

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The histone variant H2A.Z and its chaperone SRCAP are required for RNA polymerase II to access HBV chromatinDOI 10.1101/2025.11.10.687638
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