Article

Epigenetic mutational landscape in breast cancer: role of the histone methyltransferase gene KMT2D in triple negative tumors

2018-12-03

Abstract excerpt

<h4>Purpose: </h4> Epigenetic regulating proteins like histone methyltransferases produce variations in several functions, some of them associated with the generation of oncogenic processes. Mutations of genes involved in these functions have been recently associated with cancer, and strategies to modulate their activity are currently in clinical development. <h4>Methods:</h4> By using data extracted from the META...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d16c435a-8dee-57dd-8541-9dfa3824e216
DOI: 10.1101/486233

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Epigenetic mutational landscape in breast cancer: role of the histone methyltransferase gene KMT2D in triple negative tumorsDOI 10.1101/486233Read

KMT2C and KMT2D aberrations in breast cancer.Semantic proximity Read

KMT2C is a potential biomarker of prognosis and chemotherapy sensitivity in breast cancer.Semantic proximity Read

Genetic alterations of histone lysine methyltransferases and their significance in breast cancer.Semantic proximity Read

Epigenetic genes alterations in metastatic solid tumors: results from the prospective precision medicine MOSCATO and MATCH-R trialsSemantic proximity Read

Analysis of the role of mutations in the KMT 2D histone lysine methyltransferase in bladder cancerSemantic proximity Read

Pan-Cancer Analysis of Histone Methyltransferase KMT2D with Potential Implications for Prognosis and Immunotherapy in Human CancerSemantic proximity Read

Epigenetic gene alterations in metastatic solid tumours: results from the prospective precision medicine MOSCATO and MATCH-R trials.Semantic proximity Read

Mapping in silico genetic networks of the KMT2D tumour suppressor gene to uncover novel functional associations and cancer cell vulnerabilities.Semantic proximity Read

Mapping <i>in silico</i> genetic networks of the <i>KMT2D</i> tumour suppressor gene to uncover novel functional associations and cancer cell vulnerabilitiesSemantic proximity Read

Genomic alterations in KMT2 family predict outcome of immune checkpoint therapy in multiple cancersSemantic proximity Read

Methyl-CpG binding domain protein 2 plays a causal role in breast cancer growth and metastasisSemantic proximity Read

Pan-cancer analysis of SETD2 mutation and its association with the efficacy of immunotherapySemantic proximity Read